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By Dimitrios Linos (Editor), Jon A. van Heerden (Editor)

- Over two hundred beautiful illustrations, starting from intraoperative images, line drawings, diagnostic pictures, pathology slides, tables and graphs can be found to make every one case mentioned understandable and straightforward to follow.  - conventional and novel ther

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Gomez MT, Magiakou MA, Mastorakos G, Chrousos GP (1993) The pituitary corticotroph is not the rate-limiting step in the postoperative recovery of the hypothalamic pituitary adrenal axis in patients with Cushing’s syndrome. J Clin Endocrinol Metab 77:173–177 50. J Rheumatol 20:469–474 29 30 Ioannis Kyrou, Constantine Tsigos 51. Gwynne JT, Strauss JF 3rd (1982) The role of lipoproteins in steroidogenesis and cholesterol metabolism in steroidogenic glands. Endocr Rev 3:299–329 52. Hackney AC (2001) Endurance exercise training and reproductive endocrine dysfunction in men: Alterations in the hypothalamic-pituitary-testicular axis.

Patients with seasonal depression and the chronic fatigue syndrome fall into this category [32, 127]. Similarly, patients with fibromyalgia have decreased urinary free cortisol excretion and frequently complain of fatigue [50]. Hypothyroid patients also have clear evidence of CRH hyposecretion and often present depression of the “atypical” type [60]. It is interesting that in Cushing’s syndrome, the clinical manifestations of hyperphagia,weight gain,fatigue,and anergia are consistent with the suppression of the hypothalamic CRH neurons by the associated hypercortisolism [48].

Tsigos C, Crosby SR, Gibson S, et al (1993) Proopiomelanocortin is the predominant ACTH related peptide in human cerebrospinal fluid. J Clin Endocrinol Metab 76:620–624 116. Tsigos C, Kyrou I, Chala E, Tsapogas P, Stavridis JC, Raptis SA, Katsilambros N (1999) Circulating tumor necrosis factor alpha concentrations are higher in abdominal versus peripheral obesity. Metabolism 48: 1332–1335 117. Tsigos C, Papanicolaou DA, Defensor R, Mitsiadis CS, Kyrou I, Chrousos GP (1997) Dose-dependent effects of recombinant human interleukin-6 on anterior pituitary hormone secretion and thermogenesis.

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