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By Pinuccia Valagussa (auth.), Monica Castiglione, Martine J. Piccart (eds.)

Adjuvant therapy is run sooner than or as stick with as much as surgeries for breast melanoma. confirmed good fortune in utilizing scientific remedies taking into account breast maintaining methods or decreasing danger of incidence. even if there was a lot development in the direction of a therapy, together with the creation of latest exact cures, metastasizing melanoma continues to be hugely incurable.

"The adjuvant therapy of breast melanoma has develop into commonplace of care. A spectrum of biologic and prognostic components are thought of ahead of a healing procedure is carried out. during this textual content top investigators within the box speak about present administration and important investigative issues."

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Overexpression of the anti-apoptotic molecule bcl-2 is usually associated with high ER concentration and, contrary to expectation, has been associated with a higher likelihood of response to tamoxifen. 07) and longer survival [41]. 02) [42]. In another retrospective study, the interaction between bcl-2 and response to tamoxifen was evaluated in 289 patients with ER- and/or PgR-positive early breast cancer. This is the only study in which a ‘‘control’’ group of patients who did not receive treatment with tamoxifen exists, although the assignment to each group was not randomized.

Veitia R, Bissery MC, Martinez C, et al. Tau expression in model adenocarcinomas correlates with docetaxel sensitivity in tumor-bearing mice. Br J Cancer. 1998;78:871–7. 76. Rouzier R, Rajan R, Wagner P, et al. Microtubule-associated protein tau: A marker of paclitaxel sensitivity in breast cancer. Proc Natl Acad Sci U S A. 2005;102:8315–20. 77. Chang JC, Wooten EC, Tsimelzon A, et al. Gene expression profiling for the prediction of therapeutic response to docetaxel in patients with breast cancer.

Gene expression predictors of breast cancer outcomes. Lancet. 2003;361(9369):1590–6. 29. Sotiriou C, Neo SY, McShane LM, Korn EL, Long PM, Jazaeri A, et al. Breast cancer classification and prognosis based on gene expression profiles from a population-based study. Proc Natl Acad Sci U S A. 2003;100(18):10393–8. 30. Hu Z, Fan C, Oh DS, et al. The molecular portraits of breast tumors are conserved across microarray platforms. BMC Genomics. 2006;7:96. 31. Osborne CK, Bardou V, Hopp TA, et al. Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer.

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